The Hsueh lab
The Hsueh lab investigates the molecular interactions and coevolution between C. elegans and the nematophagous fungi.
What are we interested in?
The Hsueh Lab investigates the biology and evolution of predator–prey interactions between carnivorous fungi and nematodes. Using the model nematode Caenorhabditis elegans together with nematode-trapping fungi and carnivorous mushrooms, we study how predators detect, capture, and kill their prey, and how prey evolve behavioral and physiological defenses. Our research combines genetics, genomics, chemical ecology, imaging, and biochemistry to uncover the molecular mechanisms that mediate cross-kingdom interactions. By establishing fungal–worm systems as tractable experimental models, we aim to reveal fundamental principles of communication, coevolution, and adaptation in predator-prey interactions.
C. elegans
What are signals produced by nematodes that can be recognized by fungi? How does C. elegans evolve and adapt to fungal predation? Does C. elegans learn in response to predation?
Arthrobotrys oligospora
How does nematode-trapping fungus sense nematodes and develop traps? What makes the traps sticky?
Pleurotus ostreatus
How does oyster mushroom paralyze the nematodes? What are the nematocidal compounds produced by Pleurotus mushrooms?
